Cancer Metabolism: A Therapeutic Perspective

Abstract

This comprehensive review explores the complex metabolic landscape of tumors, emphasizing how cancer cells reprogram their metabolism and that of surrounding stromal cells to support growth, survival, and proliferation. The authors discuss the heterogeneity of metabolic phenotypes within tumors, the concept of metabolic coupling between different cell populations, and potential therapeutic strategies targeting these metabolic vulnerabilities.

Key Points

• Metabolic Heterogeneity: Tumors consist of diverse cell populations with distinct metabolic profiles, contributing to their adaptability and survival.
• Metabolic Coupling: Cancer cells can induce metabolic changes in stromal cells, leading to a symbiotic relationship that supports tumor progression.
• Therapeutic Targeting: Disrupting metabolic pathways, such as glycolysis and mitochondrial metabolism, presents a promising approach for cancer treatment.
• Clinical Implications: Understanding tumor metabolism can inform the development of biomarkers and guide personalized therapeutic strategies.

Conclusion

The metabolic flexibility and heterogeneity of tumors present both challenges and opportunities for cancer therapy. By targeting the unique metabolic dependencies of cancer cells and their interactions with the tumor microenvironment, novel therapeutic strategies can be developed to improve patient outcomes.