Over 580 Publications with 122,000+ Citations
Read more publications from Lunella Biotech
Primary Papers:
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High mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo
This research underscores the importance of mitochondrial function in cancer progression and metastasis. It proposes mtDNA content as a biomarker of cancer aggressiveness and presents Alovudine and other mtDNA replication inhibitors as promising anti-metastatic agents.
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In Vitro Investigation of Therapy-Induced Senescence and Senescence Escape in Breast Cancer Cells Using Novel Flow Cytometry-Based Methods
This study explores the phenomenon of therapy-induced senescence (TIS) in breast cancer cells and the subsequent escape from this state, which can contribute to cancer recurrence and treatment resistance.
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Antibiotics that target mitochondria extend lifespan in C. elegans
This study investigates the role of mitochondria in aging by assessing the effects of mitochondrial inhibitors on the lifespan of Caenorhabditis elegans (C. elegans). They observed that these treatments significantly extended the median lifespan of C. elegans
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A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity
This study details the synthesis and biological evaluation of Doxy-Myr, a novel derivative of Doxycycline designed to selectively target cancer stem cells (CSCs). Doxy-Myr demonstrated significant inhibition of CSC propagation in vitro and effectively prevented metastasis in vivo, without affecting the viability of normal cells or exhibiting antibiotic activity.
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Azithromycin and Roxithromycin define a new family of "senolytic" drugs that target senescent human fibroblasts
This study employed a senolytic assay system to identify and repurpose FDA-approved antibiotics for targeting senescent human fibroblasts. The researchers discovered that Azithromycin and Roxithromycin selectively eliminated senescent cells without affecting normal cells.
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Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study
This clinical pilot study investigates the effect of doxycycline, a known inhibitor of mitochondrial biogenesis, on cancer stem cells (CSCs) in early breast cancer patients. Immunohistochemical analyses revealed significant reductions in CSC markers CD44 and ALDH1 in tumor tissues post-treatment.
Reviews:
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High ATP Production Fuels Cancer Drug Resistance and Metastasis: Implications for Mitochondrial ATP Depletion Therapy
This study investigates the role of high mitochondrial ATP production in cancer progression, particularly its contribution to drug resistance and metastasis. By isolating ATP-high cancer cells, researchers found these cells to be more aggressive, exhibiting enhanced stem-like properties, multi-drug resistance, and increased metastatic potential.
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Cancer metabolism: a therapeutic perspective
This comprehensive review explores the complex metabolic landscape of tumors, emphasizing how cancer cells reprogram their metabolism and that of surrounding stromal cells to support growth, survival, and proliferation.
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Caveolae and signalling in cancer
This review article explores the role of caveolae—small, flask-shaped invaginations in the plasma membrane—and their principal structural protein, caveolin-1 (CAV1), in cancer biology.
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